Nanoportadores híbridos termo/pH sensibles a partir del uso de soportes inorgánicos de magnetita y sílice para la liberación controlada de fármacos antineoplásicos.
Palabras clave:
nanoportadores, magnetita, sílices mesoporosas, polímeros inteligentes, fármacos antineoplásicosResumen
Actualmente, existe una gran necesidad de preparar nanoportadores de fármacos antineoplásicos efectivos en la entrega selectiva del fármaco para mejorar su eficiencia terapéutica. Como resultado, se han diseñado nanoportadores híbridos mediante la conjugación de polímeros inteligentes con nanomateriales inorgánicos. Esto se debe a que la combinación de dos o más materiales puede mejorar sus propiedades y crear materiales con cualidades nuevas, únicas y superiores. Por lo tanto, aquí se presenta una breve revisión sobre el diseño de nanoportadores de fármacos antineoplásicos a partir de la conjugación de polímeros inteligentes con nanopartículas de magnetita (NPsFe3O4) y nanopartículas de sílices mesoporosas (MSN).
Referencias
Abasian, P., Radmansouri, M., Habibi Jouybari, M., Ghasemi, M. V., Mohammadi, A., Irani, M. & Jazi, F. S. (2019). Incorporation of magnetic NaX zeolite/DOX into the PLA/chitosan nanofibers for sustained release of doxorubicin against carcinoma cells death in vitro. International Journal of Biological Macromolecules. 121: 398-406. DOI: 10.1016/j.ijbiomac.2018.09.215.
Abbaszad, A., Mahkam, M., Davaran, S. & Hamishehkar, H. (2016). A Smart pH- responsive Nano-Carrier as a Drug Delivery System: A hybrid system comprised of mesoporous nanosilica MCM-41 (as a nano-container) & a pH- sensitive polymer (as smart reversible gatekeepers): Preparation, characterization and in vitro release studies of an anti-cancer drug. European Journal of Pharmaceutical Sciences. 93: 64-73. DOI: 10.1016/j.ejps.2016.08.005.
Amantea, B., Piazza, R., Chacon, J., Santos, C., Costa, T., Rocha, C. & Marques,
R. (2019). Esterification influence in thermosensitive behavior of copolymers PNIPAm-co-PAA and PNVCL-co-PAA in magnetic nanoparticles surface. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 575: 18-
26. DOI: 10.1016/j.colsurfa.2019.04.011.
Bagheri, E., Ansari, L., Abnous, K., Taghdisi, S., Charbgoo, F., Ramezani, M. & Alibolandi, M. (2018). Silica based hybrid materials for drug delivery and bioimaging. Journal of Controlled Release. 277: 57-76. DOI: 10.1016/j.jconrel.2018.03.014.
Bharti, C., Nagaich, U., Pal, A. & Gulati, N. (2015). Mesoporous silica nanoparticles in target drug delivery system: A review. International Journal of Pharmaceutical Investigation. 5: 124-133. DOI: 10.4103/2230-973x.160844.
Bhavsar, D., Gajjar, J. & Sawant, K. (2019). Formulation and development of smart pH responsive mesoporous silica nanoparticles for breast cancer targeted delivery of anastrozole: In vitro and in vivo characterizations. Microporous and Mesoporous Materials. 279: 107-116. DOI: 10.1016/j.micromeso.2018.12.026.
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R., Torre, L. & Jemal, A. (2020). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca: A Cancer Journal for Clinicians. 70: 313-313. DOI: 10.3322/caac.21609.
Chen, F., Zhao, T., Chen, Q., Han, L., Fang, S. & Chen, Z. (2013). Synthesis and release behavior of methotrexate from Fe3O4/PLA–PEG core/shell nanoparticles with high saturation magnetization. Materials Letters. 108: 179-
182. DOI: 10.1016/j.matlet.2013.06.108.
Deodhar, G. V., Adams, M. & Trewyn, B. G. (2017). Controlled release and intracellular protein delivery from mesoporous silica nanoparticles. Biotechnology Journal. 12: 1600408. DOI: 10.1002/biot.201600408.
Dong, K., Zhao, Z., Kang, J., Lin, L., Chen, W., Liu, J. & Lu, T. (2020). Cinnamaldehyde and Doxorubicin Co-Loaded Graphene Oxide Wrapped Mesoporous Silica Nanoparticles for Enhanced MCF-7 Cell Apoptosis. International Journal of Nanomedicine. 15: 10285-10304. DOI: 10.2147/ijn.s283981.
Dudchenko, N., Pawar, S., Perelshtein, I. & Fixler, D. (2022). Magnetite Nanoparticles: Synthesis and Applications in Optics and Nanophotonics. Materials. 15: 2601. DOI: 10.3390/ma15072601.
Ferreira, D., Domingues, S., Viana, D. & Tebaldi, M. (2020). Polymer-hybrid nanoparticles: Current advances in biomedical applications. Biomedicine & Pharmacotherapy. 131: 110695. DOI: 10.1016/j.biopha.2020.110695.
Gao, F., Wu, X., Wu, D., Yu, J., Yao, J., Qi, Q. & Mi, Y. (2020). Preparation of degradable magnetic temperature- and redox-responsive polymeric/Fe3O4 nanocomposite nanogels in inverse miniemulsions for loading and release of 5-fluorouracil. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 587: 124363. DOI: 10.1016/j.colsurfa.2019.124363.
Hadadian, Y., Masoomi, H., Dinari, A., Ryu, C., Hwang, S., Kim, S. & Yoon, J. (2022). From Low to High Saturation Magnetization in Magnetite Nanoparticles: The Crucial Role of the Molar Ratios Between the Chemicals. American Chemical Society Omega. 7: 15996-16012. DOI:10.1021/acsomega.2c01136.
Hoang, T., Cao, V., Nguyen, T., Hoang, D., Ngo, V. & Nguyen, D. (2019). Functionalized mesoporous silica nanoparticles and biomedical applications. Materials Science and Engineering: C. 99: 631-656. DOI: 10.1016/j.msec.2019.01.129.
Hu, X., Wang, Y. & Peng, B. (2014). Chitosan-Capped Mesoporous Silica Nanoparticles as pH-Responsive Nanocarriers for Controlled Drug Release. Chemistry - An Asian Journal. 9: 319-327. DOI: 10.1002/asia.201301105.
Huang, L., Liu, M., Mao, L., Huang, Q., Huang, H., Wan, Q. & Wei, Y. (2017). Surface PEGylation of mesoporous silica materials via surface-initiated chain transfer free radical polymerization: Characterization and controlled drug release. Materials Science and Engineering: C. 81: 57-65. DOI: 10.1016/j.msec.2017.07.039.
Huang, L., Wu, J., Liu, M., Mao, L., Huang, H., Wan, Q. & Wei, Y. (2017). Direct surface grafting of mesoporous silica nanoparticles with phospholipid choline- containing copolymers through chain transfer free radical polymerization and their controlled drug delivery. Journal of Colloid and Interface Science. 508: 396-404. DOI: 10.1016/j.jcis.2017.08.071.
Jermy, R., Ravinayagam, V., Alamoudi, W., Almohazey, D., Elanthikkal, S., Dafalla,
H. & Baykal, A. (2020). Tuning pH sensitive chitosan and cisplatin over spinel ferrite/silica nanocomposite for anticancer activity in MCF-7 cell line. Journal of Drug Delivery Science and Technology. 57: 101711. DOI: 10.1016/j.jddst.2020.101711.
Karesoja, M., McKee, J., Karjalainen, E., Hietala, S., Bergman, L., Linden, M. & Tenhu, H. (2013). Mesoporous silica particles grafted with poly(ethyleneoxide-block-N-vinylcaprolactam). Journal of Polymer Science Part A: Polymer Chemistry. 51: 5012-5020. DOI: 10.1002/pola.26928.
Li, H., Yu, H., Zhu, C., Hu, J., Du, M., Zhang, F. & Yang, D. (2016). Cisplatin and doxorubicin dual-loaded mesoporous silica nanoparticles for controlled drug delivery. RSC Advances. 6: 94160-94169. DOI: 10.1039/C6RA17213J.
Liu, R., Guo, Y., Odusote, G., Qu, F. & Priestley, R. (2013). Core–Shell Fe3O4 Polydopamine Nanoparticles Serve Multipurpose as Drug Carrier, Catalyst Support and Carbon Adsorbent. ACS Applied Materials & Interfaces. 5: 9167- 9171. DOI: 10.1021/am402585y.
Liu, X., Yu, D., Jin, C., Song, X., Cheng, J., Zhao, X. & Zhang, G. (2014). A dual responsive targeted drug delivery system based on smart polymer coated mesoporous silica for laryngeal carcinoma treatment. New Journal of Chemistry. 38: 4830-4836. DOI: 10.1039/c4nj00579a.
Liu, Y., Chen, D., Shang, P. & Yin, D. (2019). A review of magnet systems for targeted drug delivery. Journal of Controlled Release. 302: 90-104. DOI: 10.1016/j.jconrel.2019.03.031.
Matei, C., Buhǎlţeanu, L., Berger, D. & Mitran, R. (2019). Functionalized mesoporous silica as matrix for shape-stabilized phase change materials. International Journal of Heat and Mass Transfer. 144: 118699. DOI: 10.1016/j.ijheatmasstransfer.2019.118699.
Morfin-Gutiérrez, A., Meléndez-Ortiz, H., Puente-Urbina, B. & García-Cerda, L. (2018). Synthesis of Poly(N-vinylcaprolactam)-Grafted Magnetite Nanocomposites for Magnetic Hyperthermia. Journal of Nanomaterials. 2018: 9562020. DOI:10.1155/2018/9562020.
Morfin-Gutierrez, A., Sánchez-Orozco, J., García-Cerda, L., Puente-Urbina, B. & Meléndez-Ortiz, H. (2020). Preparation and characterization of nanocomposites based on poly(N-vinycaprolactam) and magnetic nanoparticles for using as drug delivery system. Journal of Drug Delivery Science and Technology. 60: 102028. DOI: 10.1016/j.jddst.2020.102028.
Mu, X., Zhang, F., Kong, C., Zhang, H., Zhang, W., Ge, R. & Jiang, J. (2017). EGFR- targeted delivery of DOX-loaded Fe3O4@ polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy. International Journal of Nanomedicine. 12: 2899. DOI: 10.2147/ijn.s131418.
Niculescu, V. (2020). Mesoporous Silica Nanoparticles for Bio-Applications. Frontiers in Materials. 7. DOI: 10.3389/fmats.2020.00036.
Palanikumar, L., Kim, J., Oh, J., Choi, H., Park, M., Kim, C. & Ryu, J. (2018). Hyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy. ACS Biomaterials Science & Engineering. 4: 1716-1722.
DOI:10.1021/acsbiomaterials.8b00218.
Peponi, L., Arrieta, M., Mujica-Garcia, A. & López, D. (2017). 6 - Smart Polymers. In
C. F. Jasso-Gastinel and J. Kenny (Eds.), Modification of Polymer Properties (pp. 131-154). William Andrew Publishing. DOI: 10.1016/B978-0-323-44353- 1.00006-3.
Pham, X., Nguyen, T., Pham, T., Tran, T., & Tran, V. (2016). Synthesis and characterization of chitosan-coated magnetite nanoparticles and their application in curcumin drug delivery. Advances in Natural Sciences: Nanoscience and Nanotechnology. 7: 045010. DOI:10.1088/2043- 6262/7/4/045010.
Pon-On, W., Tithito, T., Maneeprakorn, W., Phenrat, T. & Tang, I. (2019). Investigation of magnetic silica with thermoresponsive chitosan coating for drug controlled release and magnetic hyperthermia application. Materials Science and Engineering: C. 97, 23-30. DOI: 10.1016/j.msec.2018.11.076
Porrang, S., Rahemi, N., Davaran, S., Mahdavi, M. & Hassanzadeh, B. (2021). Synthesis of temperature/pH dual-responsive mesoporous silica nanoparticles by surface modification and radical polymerization for anti- cancer drug delivery. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 623: 126719. DOI: 10.1016/j.colsurfa.2021.126719.
Rahoui, N., Jiang, B., Hegazy, M., Taloub, N., Wang, Y., Yu, M. & Huang, Y. (2018). Gold modified polydopamine coated mesoporous silica nano-structures for synergetic chemo-photothermal effect. Colloids and Surfaces B: Biointerfaces. 171: 176-185. DOI: 10.1016/j.colsurfb.2018.07.015.
Rejeeth, C., Vivek, R. & Kannan, S. (2015). A novel magnetic drug delivery nanocomplex with a cisplatin-conjugated Fe3O4 core and a PEG- functionalized mesoporous silica shell for enhancing cancer drug delivery efficiency. RSC Advances. 5: 94534-94538. DOI:10.1039/c5ra19274a.
Rejeeth, C., Vivek, R., NipunBabu, V., Sharma, A., Ding, X. & Qian, K. (2017). Cancer nanomedicine: from PDGF targeted drug delivery. MedChemComm. 8: 2055-2059. DOI:10.1039/c7md00391a.
Rivera-Escobedo, L., Sánchez-Orozco, J., García-Cerda, L., Puente-Urbina, B., García-Uriostegui, L. & Meléndez-Ortiz, H. (2023). Hafnium-doped nano- magnetite/poly(N-vinylcaprolactam) composites for doxorubicin release. Materials Chemistry and Physics. 301: 127670. DOI: 10.1016/j.matchemphys.2023.127670.
Sánchez-Orozco, J., García-Cerda, L., Puente-Urbina, B. & Meléndez-Ortiz, H. (2023). Poly(N-vinylcaprolactam-co-2-(diethylamino)ethylmethacrylate) coated Fe3O4@SiO2 core-shell magnetic nanoparticles for controlled doxorubicin delivery. Journal of Drug Delivery Science and Technology. 81: 104253. DOI: 10.1016/j.jddst.2023.104253.
Sánchez-Orozco, J., Meléndez-Ortiz, H., Puente-Urbina, B., Rodríguez-Fernández, O., Martínez-Luévanos, A. & García-Cerda, L. A. (2023). Synthesis and Characterization of a pH- and Temperature-Sensitive Fe3O4-SiO2- Poly(NVCL-co-MAA) Nanocomposite for Controlled Delivery of Doxorubicin Anticancer Drug. Polymers. 15: 968. DOI: 10.3390/polym15040968.
Shen, B., Ma, Y., Yu, S. & Ji, C. (2016). Smart Multifunctional Magnetic Nanoparticle- Based Drug Delivery System for Cancer Thermo-Chemotherapy and Intracellular Imaging. ACS Applied Materials & Interfaces. 8: 24502-24508. DOI:10.1021/acsami.6b09772.
Sriraman, S., Aryasomayajula, B. & Torchilin, V. (2014). Barriers to drug delivery in solid tumors. Tissue Barriers. 2: e29528. DOI:10.4161/tisb.29528.
Tian, B., Liu, S., Wu, S., Lu, W., Wang, D., Jin, L. & Quan, Z. (2017). pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin. Colloids and Surfaces B: Biointerfaces. 154: 287-296. DOI: 10.1016/j.colsurfb.2017.03.024.
Tian, Y., Glogowska, A., Zhong, W., Klonisch, T. & Xing, M. (2013). Polymeric mesoporous silica nanoparticles as a pH-responsive switch to control doxorubicin intracellular delivery. Journal of Materials Chemistry B. 1: 5264- 5272. DOI:10.1039/c3tb20544d.
Vallet-Regí, M., Schüth, F., Lozano, D., Colilla, M. & Manzano, M. (2022). Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades? Chemical Society Reviews. 51: 5365-5451. DOI:10.1039/d1cs00659b.
Wallyn, J., Anton, N. & Vandamme, T. (2019). Synthesis, Principles, and Properties of Magnetite Nanoparticles for In Vivo Imaging Applications-A Review. Pharmaceutics. 11: 601. DOI:10.3390/pharmaceutics11110601.
Wang, G., Dong, J., Yuan, T., Zhang, J., Wang, L. & Wang, H. (2016). Visible Light and pH Responsive Polymer-Coated Mesoporous Silica Nanohybrids for Controlled Release. Macromolecular Bioscience. 16: 990-994. DOI:10.1002/mabi.201600008.
Wang, L., Jang, G., Ban, D. K., Sant, V., Seth, J., Kazmi, S. & Lal, R. (2017). Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls: Nanoshuttles for targeted on-demand theranostics.
Bone Research. 5: 17051. DOI:10.1038/boneres.2017.51.
Wen, H., Guo, J., Chang, B. & Yang, W. (2013). pH-responsive composite microspheres based on magnetic mesoporous silica nanoparticle for drug delivery. European Journal of Pharmaceutics and Biopharmaceutics. 84: 91-
98. DOI: 10.1016/j.ejpb.2012.11.019.
Yadavalli, T., Ramasamy, S., Chandrasekaran, G., Michael, I., Therese, H. A. & Chennakesavulu, R. (2015). Dual responsive PNIPAM–chitosan targeted magnetic nanopolymers for targeted drug delivery. Journal of Magnetism and Magnetic Materials. 380: 315-320. DOI: 10.1016/j.jmmm.2014.09.035.
Yang, Y., Zhao, B., Li, Z., Lin, W., Zhang, C., Guo, X. & Zhang, L. (2013). pH- sensitive micelles self-assembled from multi-arm star triblock co-polymers poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b- poly(poly(ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery. Acta Biomaterialia. 9: 7679-7690. DOI: 10.1016/j.actbio.2013.05.006.
Yao, X., Chen, X., He, C., Chen, L. & Chen, X. (2015). Dual pH-responsive mesoporous silica nanoparticles for efficient combination of chemotherapy and photodynamic therapy. Journal of Materials Chemistry B. 3: 4707-4714. DOI:10.1039/c5tb00256g.
Yuan, N., Li, S. & Li, G. (2018). Sodium alginate coated mesoporous silica for dual bio-responsive controlled drug delivery. Journal of Drug Delivery Science and Technology. 46: 348-353. DOI: 10.1016/j.jddst.2018.05.026.
Zhang, Y., Ang, C. Y., Li, M., Tan, S. Y., Qu, Q., Luo, Z. & Zhao, Y. (2015). Polymer- Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery. ACS Applied Materials & Interfaces. 7: 18179-18187. DOI:10.1021/acsami.5b05893.
