Cannabis sativa: propiedades bioquímicas relevantes para uso medicinal
Palabras clave:
Cannabis sativa, Cáñamo industrial, Farmacología molecular de los cannabinoidesResumen
El objetivo del presente estudio es analizar la literatura relacionada con el uso medicinal de Cannabis sativa tomando aspectos biológicos, bioquímicos y medicinales. Se exploran los marcos regulatorios que rigen los productos herbales en México, destacando la importancia de una regulación sanitaria sólida. Se examinan los aspectos biológicos e históricos de la planta, propiedades bioquímicas de los extractos de semillas de cáñamo (Cannabis sativa L.). La revisión profundiza en la descripción morfológica y el contexto histórico de Cannabis sativa, incluidas sus características de cáñamo industrial. Se examinan los usos de extractos de cáñamo en la medicina tradicional, alternativa y complementaria, haciendo hincapié en el uso histórico de las plantas con fines medicinales. Se describe el sistema endocannabinoide y la farmacología molecular de los fitocannabinoides, arrojando luz sobre su potencial terapéutico y futuras investigaciones de aprovechamiento de su potencial medicinal.
Referencias
Abate, G., Uberti, D., & Tambaro, S. (2021). Potential and limits of cannabinoids in Alzheimer's disease therapy. Biology, 10(6): 1–21. https://doi.org/10. 3390/biology10060542
Alba Tamayo, A.K., & Peña, R. (2021). Therapeutic use of Cannabis sativa in Parkinson's neurodegenerative disease as a pharmacological alternative, in Bogotá Technology Corporation.
Aso, E., Andrés-Benito, P., Carmona, M., Maldonado, R., & Ferrer, I. (2016). Cannabinoid receptor 2 participates in amyloid-β processing in a mouse model of Alzheimer's disease but plays a minor role in the therapeutic properties of a cannabis-based medicine. Journal of Alzheimer's Disease, 51(2): 489–500. https://doi.org/10.3233/JAD-150913
Carrasco-Nuñez, N., Cabeza Salinas, M., & Pérez-González, M.L . (2020). In vitro effect of rosemary oil (Rosmarinus officinalis) as an inhibitor of acetylcholinesterase activity as an alternative therapy in Alzheimer's Syndrome. Health Problem, 26: 93–102. https://saludproblemao js.xoc.uam.mx/i ndex.php/saludproblema/article/view/649/644
Cheng, D., Low, J.K., Logge, W., Garner, B., & Karl, T. (2014). Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice. Psychopharmacology, 231(15): 3009–3017. https://do i.org/10.1007/s00213-014-3478-5
Citti, C., Braghiroli, D., Vandelli, M.A., & Cannazza, G. (2018). Pharmaceutical and biomedical analysis of cannabinoids: A critical review. Journal of Pharmaceutical and Biomedical Analysis, 14:, 565–579. https://doi.org/ 10.10 16/j.jpba.2017.06.003
Cristino, L., Bisogno, T., & Di Marzo, V. (2020). Cannabinoids and the expanded endocannabinoid system in neurological disorders. Nature Reviews Neurology, 16(1): 9–29. https://doi.org/10.1038/s41582-019-0284-z
Enamorados, Y., Ilyina, A., Belmares, S., Vargas, A., Martínez, J., & Segura, E. (2017). Mexican plants can be used with an inhibitory effect on the enzyme Acetylcholinesterase as a possible treatment for Alzheimer's disease. Mexican Journal of Pharmaceutical Sciences, 48(4): 7–16.
Espinosa-Jovel, C. (2023). Cannabinoids in epilepsy: Clinical efficacy and pharmacological considerations. Neurology, 38(1): 49–55. https://doi.org /10.1016/j.nrl.2020.02.005
Esposito, G., Scuderi, C., Valenza, M., Togna, GI, Latina, V., de Filippis, D., Cipriano, M., Carratù, MR, Iuvone, T., & Steardo, L. ( 2011). Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement. PLOS ONE, 6(12). https://doi.org/10.1371 /journal.p one.0028668
Furqan, T., Batool, S., Habib, R., Shah, M., Kalasz, H., Darvas, F., Kuca, K., Nepovimova, E., Batool, S., & Nurulain, SM ( 2020). Cannabis constituents and acetylcholinesterase interaction: Molecular docking, in vitro studies and association with CNR1 RS806368 and ACHE RS17228602. Biomolecules, 10(5): 1–17. https://doi.org/10.3390/biom10050758
Hann, V., & Chazot, P.L. (2004). G-proteins. Current Anesthesia and Critical Care, 15(1): 79–81. https://doi.org/10.1016/j.cacc.2004.02.004
Castro Barragán, J.., Daniels García, M., Martínez Visbal, A. (2020). Receptores cannabinoides y vías de modulación de dolor. Revista Ciencias Biométicas, 7(1), 93–103. DOI: 10.32997/rcb-2016-2935
Karl, T., Cheng, D., Garner, B., & Arnold, J.C. (2012). The therapeutic potential of the endocannabinoid system for Alzheimer's disease. Expert Opinion on Therapeutic Targets, 16(4): 407–420. https://doi.org/10.1517/14728222. 2012.671812
Khazaei, H., Pesce, M., Patruno, A., Aneva, I.Y., & Farzaei, M.H. (2021). Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies. Phytotherapy Research, 35(4): 1697–1718. https://doi.org/10.1002/ptr.6903
Lee, J., Kwon, S., Jin, C., Cho, S.Y., Park, S.U., Jung, W.S., Moon, S.K., Park, J.M., Ko, C.N., & Cho, K.H. (2022). Traditional East Asian Herbal Medicine Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis. Pharmaceuticals: 15(2), 1–39. https://doi.org/10.3390/ph15020174
López, G.E.Á., Brindis, F., Niizawa, S.C., & Martínez, R.V. (2014). Cannabis sativa L., a unique plant. Revista Mexicana de Ciencias Farmacéuticas, 45(4):6.
Maroon, J., & Bost, J. (2018). Review of the neurological benefits of phytocannabinoids. Surgical Neurology International, 9(1). https://doi.org/ 10.4103/SNI.SNI_45_18
Martín, A.M., Brera, B., Spuch, C., & Carro, E. (2012). Prolonged oral cannabinoid administration prevents neuroinflammation, lowers b-amyloid levels, and improves cognitive performance in Tg APP 2576 mice. Journal of Neuroinflammation, 9(8).
Mirabal Gómez, R., & Koh, O. (2019). Scientific education and traditional medicine. A comparison between Mexico and South Korea. Magazine of El Colegio de San Luis, 19: 39–59. https://doi.org/10.21696/rcsl9192019916
Mooko, T., Bala, A., Tripathy, S., Kumar, C.S., Mahadevappa, C.P., Chaudhary, S., & Matsabisa, M.G. (2021). Cannabis sativa L. Flower and Bud Extracts Inhibited In Vitro Cholinesterases and β-Secretase Enzymes Activities: Possible Mechanisms of Cannabis Use in Alzheimer Disease. Endocrine, Metabolic & Immune Disorders - Drug Targets, 22(3): 297–309. https://doi.org/10.2174 /1871530321666210222124349
Moreno, T., Montanes, F., Tallon, S., Fenton, T., & King, J.W. (2020). Extraction of cannabinoids from hemp (Cannabis sativa L.) using high-pressure solvents: An overview of different processing options. Journal of Supercritical Fluids, 161: 104850. https://doi.org/10.1016/j.supflu.2020.104850
Petrović, M., Debeljak, Ž., Kezić, N., & Džidara, P. (2015). Relationship between cannabinoid content and composition of fatty acids in hempseed oils. Food Chemistry, 170: 218–225. https://doi.org/10.1016/j.foodchem.2014.08 .039
Plancarte-Sánchez, R., Mansilla-Olivares, A., De los Reyes-Pacheco, V.A., & Meneses-González, F. (2019). Therapeutic applications due to the action of cannabinoids. Gaceta Medica de Mexico, 155(3): 307–318. https://doi.org /10.24875/GMM.1 8004928
Ramírez, C.L., Fanovich, M.A., & Churio, MS (2018). Cannabinoids: Extraction Methods, Analysis, and Physicochemical Characterization. In: Studies in Natural Products Chemistry. (1st ed., Vol. 61). Elsevier BV https://doi. org/10.1016/B97 8-0-444-64183-0.00004-X
Gil-Rodríguez, J.R., Fernanda Herrera-Rojas, M.F., & Mitre-Velasco, Y., Santamaría-Rivas, C. (2020). Compuestos activos en plantas utilizadas en la medicina tradicional mexicana. Revista RD, 6(16): 175–200. http://rd.buap.mx/ojs-dm/index.php/rdicuap/article/download/268/254
Rodríguez-Hernández, A.A., Flores-Soria, F.G., Patiño-Rodríguez, O., & Escobedo-Moratilla, A. (2022). Sanitary Registries and Popular Medicinal Plants Used in Medicines and Herbal Remedies in Mexico (2001–2020): A Review and Potential Perspectives. Horticulturae, 8(5):377. https://doi.org/10.3390/ horticulturae805 0377
Serra Bisbal, JJ, Melero Lloret, J., Martínez Lozano, G., & Fagoaga, C. (2020). Plant species as food antioxidants. Nereis. Interdisciplinary Ibero-American Journal of Methods, Modeling and Simulation, 12: 71–90. https://doi.org /10.46583/nere is_2020.12.577
Tlaxca Santamaria, J.F. (2021) Propagación de cannabis: una alternativa en la producción de cannabinoides para su utilización clínica. RD – ICUAP, 7 (21): 154 – 164. DOI: 10.32399/icuap.rdic.2448-5829.2021.21.623
Tofiño-Rivera, A.P., Ortega-Cuadros, M., Melo-Ríos, A., & Mier-Giraldo, H.J. (2017). Technological surveillance of aromatic plants: From research to the consolidation of the Colombian agricultural chain. Corpoica Agricultural Science and Technology, 18(2): 353–377. https://doi.org/10.21930 /rcta.vol18_num2 _art:636
Wu, J., Bie, B., Yang, H., Xu, J.J., Brown, D.L., & Naguib, M. (2013). Activation of the CB2 receptor system reverses amyloid-induced memory deficiency. Neurobiology of Aging, 34(3): 791–804. https://doi.org/10.1016/j.neur obiolaging. 2012.06.011