Respuesta inmunitaria del perro a la arginina cinasa de la garrapata Rhipicephalus sanguineus
Palabras clave:
Rhipicephalus sanguineus, respuesta inmune, Arginina cinasa, alergenosResumen
Las garrapatas son ectoparásitos que afectan al humano, animales de compañía y de producción, siendo vectores de patógenos bacterianos y virales. Rhipicephalus sanguineus, comunmente conocida como garrapata café, es el ectoparásito más ampliamente distribuido en México y el mundo. Los perros son parte de su ciclo de vida, siendo de gran interés en temas de salud pública y veterinaria. En esta revisión se presenta información relevante acerca de la respuesta inmune a la garrapata café en perros. En particular, contribuimos al conocimiento sobre la potencial respuesta inmune del perro a la proteína arginina cinasa de garrapata, la cual es un alérgeno para humanos, sin embargo se desconoce si en perros ocurre un mecanismo análogo.
Referencias
Abdoli, F., Mostafavi, E., Esmaeili, S., Rohani, M. (2022) Molecular detection and identification of Rickettsia spp. in collected ticks from domestic animals in Southeastern of Iran. Comparative Immunology, Microbiology and Infectious Diseases, 85: 101798.
Adeyemi, O.S., y C.G. Whiteley. (2013). Interaction of nanoparticles with arginine kinase from Trypanosoma brucei: Kinetic and mechanistic evaluation. International Journal of Biological Macromolecules, 62: 450-456.
Alvarez, G., C. Rosales, y R. Sepulveda. (2014). Rocky Mountain Spotted Fever, A Reemerging Disease in Arizona and Sonora- Case Study. Journal of Case Reports and Studies, 3: 12-14.
Alvarez-Hernandez G., Villegas-Trejo A., Ratti V., Teglas M y Wallace D. Y. (2022). Modeling of Control Efforts against Rhipicephalus sanguineus, the vector of Rocky Mountain Spotted Fever in Sonora Mexico. Insects, 13 (263): 1-22.
Amin, O.M. (1970). The circadian rhythm of dropping of engorged larvae and nymphs of the American dog tick Dermacentor variabilis Say (Acarina: Ixodidae). Journal of Medical Entomology, 7(2): 251-255.
Arlian, L.G. (2002). Arthropod Allergens and Human Health. Annual Review of
Entomology, 47: 395-433.
Astier, C., M. Morisset, O. Roitel, F. Codreanu, S. Jacquenet, P. Franck, y V. Ogier. (2006). Predictive value of skin prick tests using recombinant allergens for diagnosis of peanut allergy. Jornal of Allergy and Clinical Immunology, 118(1): 250-256.
Auerswald, L., y A. Lopata. (2005). Insects – diversity and allergy: review article.
Current Allergy and Clinical Immunology, 18(2): 58-60.
Barillas-Mury, C., Ribeiro, J.M.C., Valenzuela, J.G. (2022) Understanding pathogen survival and transmission by arthropod vectors to prevent human disease. Science, 377(6614): 1507
Bechara, G.H., J. Morelli, y S.M.P. J. (2006). Skin Test and Tick Immune Status in Susceptible and Resistant Cattle in Brazil. Annals of the New York Academy of Sciences, 916: 570-575.
Bera, R.K. (2009). The global importance of ticks. Current Science, 5: 643-645. Binder, M., V. Mahler, B. Hayek, R. Wolfgang, M. Schöller, S. Prozell, P. Valent, R.
Valenta, S. Prozell, G. Wiedermann, P. Valent, R. Valenta, y M. Duche. (2001). Molecular and Immunological Characterization of Arginine Kinase from the Indianmeal Moth, Plodia interpunctella, a Novel Cross-Reactive Invertebrate Pan-Allergen. Journal of Immunology, 167(9): 5470-5477.
Bircher, A.J. (2005). Systemic Immediate Allergic Reactions to Arthropod Stings and Bites. Dermatology, 210(2): 119-127.
Bobolea, I., C. Pastor-Vargas, y V. Iraola. (2011). Arginine Kinase from the Cellar Spider (Holocnemus pluchei): A New Asthma-Causing Allergen. International Archives of Allergy and Immunology, 155(2): 180-186.
Braunger, K., Ahn., J., Jore, M.M., Johnson, S., Tang, T.T.L., Pedersen, D.V., Andersen G.R., Lea, S.M. (2022). Structure and function of a family of tick- derived complement inhibitors targeting properdin. Nature Communications, 13(1): 317-320.
Brown, A.E., R.M. France, y S.H. Grossman. (2004). Purification and characterization of arginine kinase from the American cockroach (Periplaneta americana). Archives of Insect Biochemistry and Physiology, 56(2): 51–60.
Castillo-Martínez A., Cueto-Medina S.M., Valdés-Perezgasga M. T., Sánchez- Ramos F.J., López-Hernández J., Hernández-Rodríguez S. y Ortega-Morales
A. I. (2017). Detection of Rickettsia Rickettsii Brumpt (Rickettsiales: Rickettsiaceae) in the Brown Dog Tick Rhipiephalus sanguineus Latreille (Ixodida: Ixodidae) In the Comarca Lagunera, A reemergent Spotted Fever Zone in Mexico. Acta Zoológica Mexicana, 33(2): 339-344.
Cavassani, K.A., J.C. Aliberti, A.R. V. Dias, J.S. Silva, y B.R. Ferreira. (2005). Tick saliva inhibits differentiation, maturation and function of murine bone-marrow- derived dendritic cells. Immunology, 114(2): 235-245.
Chabud, A.G. (1950). L’infestation par des ixodinés provoque-t-elle une immunité
chez l’hôte. Annales de Parasitologie, 25(5-6): 474-479.
Chen, H., H. Mao, M. Cao, Q. Cai, W. Su, Y. Zhang, y G. Liu. (2013). Purification, physicochemical and immunological characterization of arginine kinase, an allergen of crayfish (Procambarus clarkii). Food and Chemical Toxicology, 62: 475-484
Chinery, W.A., y E. Ayitey-Smith. (1977). Histamine blocking agent in the salivary gland homogenate of the tick Rhipicephalus sangineus sanguineus. Nature, 265(5592): 366-367.
Chmelar, J., C.J. Oliveira, P. Rezacova, I.M.B. Francischetti, Z. Kovarova, G. Pejler,
P. Kopacek, M.C. Ribeiro, M. Mares, J. Kopecky, y M. Kotsyfakis. (2011). A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood, 117(2): 736-744.
Commins, S.P., y T.A.E. Platts-Mills. (2013). Tick bites and read meat allergy.
Current Opinion in Clinical Immunology, 13(4): 354-359.
Cruz-Bacab, L.E., Perez-De la Cruz, M.C., Zaragoza-Vera, C.V., Zaragoza-Vera, M., Arjona-Jimenez, G., Lesher-Gordillo, J.M., Baak-Baak, C.M., Cigarroa-Toledo, N., Machain-Williams, C.I., Garcia-Rejon, J.E., Gonzalez-Garduño, R., Torres- Chable, O.M. (2921) Prevalence and Factors Associated with Ectoparasite Infestations in Dogs from the State of Tabasco, Mexico. Journal of Parasitology. 107(1): 29-38.
Dai, J., S. Narasimhan, L. Zhang, L. Liu, P. Wang, y E. Fikrig. (2010). Tick Histamine Release Factor Is Critical for Ixodes scapularis Engorgement and Transmission of the Lyme Disease Agent. PLoS Pathogens, 6(11): e1001205.
Dantas-Torres, F. (2008). The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): From taxonomy to control. Veterinary Parasitology, 152(3-4): 173-185.
Dantas-Torres, F., A. Giannelli, y D. Otranto. (2012). Starvation and overwinter do not affect the reproductive fitness of Rhipicephalus sanguineus. Veterinary Parasitology. 185(2-4): 260-264.
Davi, G., y C. Patrono. (2007). Platelet Activation and Atherothrombosis. The New England Journal of Medicine. 357: 2482-2492.
De Oliveira, P.R., G.H. Bechara, S.E. Denardi, K.C. Saito, E.T. Nunes, M.P.J. Szabó, y M.I.C. Mathias. (2005). Comparison of the external morphology of Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) ticks from Brazil and Argentina. Veterinary Parasitology, 129(1-2): 139-147.
Delves, P.J., S.J. Martin, D.R. Burton, y I.M. Roitt. (2017). Roitt’s Essential
Immunology, 30.a ed. Wiley Blackwell, Oxford. pp 556.
Dzul-Rosado K., Lugo-Caballero C., Tello-Martin R., López-Avila K. y Zavala-Castro
J. (2017). Direct evidence of Rickettsia typhi infection in Rhipicephalus sanguineus ticks and their canine hosts. Open Veterinary Journal, 7(2): 165- 169.
Dzul-Rosado K. R., Reyes-Novelo E., Lugo-Caballero C., Cuxim-Koyoc A. D., Collí- Padrón F., Tello-Martín R., López-Ávila K.B., Palma-Chan A., Peniche-Lara G. y Ruiz-Piña H. A. (2021). Urban ecology of hosts and vectors of Rickettsia in a rickettsiosis-endemic city of the Yucatan peninsula, Mexico. Acta Tropica, 216: 105832
Esch, R.E., C.J. Hartsell, R. Crenshaw, y R.S. Jacobson. (2001). Common Allergenic Pollens, Fungi, Animals, and Arthropods. Clinical Reviews in Allergy and Immunology, 21:261-292.
Fei, D., Q. Liu, F. Chen, Y. Yang, Z. Chen, y M. Cao. (2016). Assessment of the sensitizing capacity and allergenicity of enzymatic cross-linked arginine kinase, the crab allergen. Molecular Nutrition and Food Research, 60(7):1707-1718.
Foley J., Tinoco-Gracia L., Rodriguez-Lomelí M., Estrada-Guzmán J., Fierro M., Mattar-Lopez E., Peterson A., Pascoe E., Gonzalez Y., Hori-Oshima S., Armstrong P.A., Lopez G., Jacome-Ibarra M., Paddock C. D. y Zazueta O. E.
(2019). Unbiases Assessment of Abundance of Rhipicephalus sanguineus lato Ticks, Canine Exposure to Spotted Fever Group Rickettsia, and Risk Factors in Mexicali, México. American Journal of Tropical Medicine and Hygiene, 101(1): 22-32.
Francischetti, I.M.B. (2010). Platelet aggregation inhibitors from hematophagous animals. Toxicon, 56(7): 1130-1144.
Galindo-Velasco E., Cruz-Vázquez C., Díaz-Chapula H., Lezama-Gutierrez R. y Chan-Copul W. (2020). Annual Infestation Pattern of Rhipicephalus sanguineus Sensu Lato on Naturally Infested Dogs in a Tropical Sub-Humid Region of Mexico. Southwestern Entomologist, 45(2): 351-356
García-Orozco, K.D., E. Aispuro-Hernández, G. Yepiz-Plascencia, A.M. Calderón- De-La-Barca, y R.R. Sotelo-Mundo. (2007). Molecular characterization of arginine kinase, an allergen from the shrimp Litopenaeus vannamei. International Archives of Allergy and Immunology, 144(1): 23-28.
González-Morteo C., De la Cruz-Moreno O., Álvarez-Guerrero C. y Borrayo- González J. (2017). A presence of structures suggestive of Ehrlichiosis in dogs from Tepic city Nayarit. Abanico Veterinario, 7(3): 72-82.
Gore, J.C., y C. Schal. (2007). Cockroach Allergen Biology and Mitigation in the Indoor Environment. Annual Review of Entomology, 52:439-463.
Gould, H.J., B.J. Sutton, A.J. Beavil, R.L. Beavil, N. Mccloskey, H.A. Coker, D. Fear, y L. Smurthwaite. (2003). The Biology of IgE and the Basis of Allergic Disease. Annual Review of Immunology, 21: 579-628.
Gray, J., F. Dantas-Torres, A. Estrada-Peña, y M. Levin. (2013). Systematics and ecology of the brown dog tick, Rhipicephalus sanguineus. Ticks and Tick-borne Diseases, 3: 171-180.
Guglielmone, A. A. (2010). Zootaxa, The Argasidae, Ixodidae and Nuttalliellidae (Acari: Ixodida) of the world. Zootaxa, 6: 1-28.
Hamsten, C., M. Starkhammar, T.A.T. Tran, M. Johansson, U. Bengtsson, G. Ahle, y M. Van Hage. (2013). Identification of galactose-a-1,3-galactose in the gastrointestinal tract of the tick Ixodes Ricinus: possible relationship with red meat allergy. Allergy, 68(4): 549-552.
Hayley D. Y., William L. N., Mariana, C., Nathan C. N. y Laura A. (2018). Serologic
assessment for exposure to spotted fever group rickettsiae in dogs in the Arizona-Sonora border region. Zoonoses and Public Health, 65: 984-992.
Hilger, C., A. Kuehn, M. Raulf, y T. Jakob. (2014). Cockroach, tick, storage mite and other arthropod allergies: Where do we stand with molecular allergy diagnostics? Allergo Journal International, 23: 172-178.
Hoffmann, A., P. Walsmann, R. G., M. Paintz, y F. Markwardt. (1991). Isolation and characterization of a thrombin inhibitor from the tick Ixodes ricinus. Pharmazie, 46(3): 209–212.
Hoffman, D.R. (2008). Structural biology of allergens from stinging and biting insects.
Current Opinion in Allergy and Clinical Immunology, 8(4): 338-342.
Inokuma, H., K. Tamura, y T. Onishi. (1997). Dogs develop resistance to
Rhipicephalus sanguineus. Veterinary Parasitology, 68(3): 295-297.
Kashino, S.S., J. Resende, A. Maria, S. Sacco, C. Rocha, L. Proença, W.A. Carvalho, A.A. Firmino, R. Queiroz, M. Benavides, L.J. Gershwin, y I.K.F. De Miranda. (2005). Boophilus microplus: The pattern of bovine immunoglobulin isotype responses to high and low tick infestations. Experimental Parasitology, 110(1): 12-21.
Kaufman, R.W. (1989). Tick-host interaction: A synthesis of current concepts.
Parasitology Today, 5(2): 47-56.
Kazimírová, M., y I. Štibrániová. (2013). Tick salivary compounds: their role in modulation of host defences and pathogen transmission. Frontiers in Cellular and Infection Microbiology, 3: 43-46.
Liu, Z., L. Xia, Y. Wu, Q. Xia, J. Chen, y K.H. Roux. (2009). Identification and Characterization of an Arginine Kinase as a Major Allergen from Silkworm (Bombyx mori) Larvae. International Archives of Allergy of Immunology, 150(1): 8-14.
López-Pérez A.M., Chaves A., Sánchez-Montes S., Foley P., Uhart M., Barrón- Rodríguez J., Becker I., Suzán G., Foley J. (2022). Diversity of rickettsiae in domestica, synanthropic, and sylvatic mammals and their ectoparasites in a spotted fever-epidemic region at the western US-Mexico border. Transboundary and Emerging Diseases, 69(2): 609-622.
Lorusso, V., F. Dantas-Torres, R.P. Lia, V.D. Tarallo, N. Mencke, G. Capelli, y D.
Otranto. (2010). Seasonal dynamics of the brown dog tick, Rhipicephalus sanguineus, on a confined dog population in Italy. Medical and Veterinary Entomology, 24(3): 309-315.
Louly, C.C.B., S.F. Soares, D.N. Silveira, O.J.S. Neto, A.C. Silva, y L.M.F. Borges. (2009). Differences in the susceptibility of two breeds of dogs, English cocker spaniel and beagle, to Rhipicephalus sanguineus (Acari: Ixodidae). International Journal of Acarology, 35(1): 25-32.
Montero, C., M. Garrido, L. Cortés, M. Henry, y F. Hernández. (2005). Identificación y caracterización de Arginina Cinasa, un probable alergeno del mosquito Anopheles albimanus. Investigación Universitaria Multidisciplinaria: Revista de Investigación de la Universidad Simón Bolívar, 4(4): 41-47.
Mumcuoglu, K.Y., K. Frish, B. Sarov, E. Manor, E. Gross, Z. Gat, y R. Galun. (1993). Ecological studies on the brown dog tick Rhipicephalus sanguineus (Acari: Ixodidae) in southern Israel and its relationship to spotted fever group rickettsiae. Journal of Medical Entomology, 30(1): 114-121.
Nandy, A., Häfner, D., y Klysner, S. (2015). Recombinant allergens in specific immunotherapy. Allergo Journal International, 24: 143-151.
Nelson, D.L., y M.M. Cox. (2013). Principles of Biochemistry, 6th ed. New York. Pp.
1198.
Nunen, S.V. (2015). Tick-induced allergies: mammalian meat allergy, tick anaphylaxis and their significance. Asia Pacific Allergy, 5(1): 3-16.
Nuttall, P.A. (1999). Pathogen-tick-host interactions: Borrelia burgdorferi and TBE virus. Zentralblatt für Bakteriologie, 289(5-7): 492-505.
Nuttall, P.A., y M. Labuda. (2004). Tick-host interactions: Saliva-activated transmission. Parasitology, 129 (Suppl.): S177-189
O’Hehir, R.E., S.T. Holgate, y A. Sheikh. (2017). Middleton’s Allergy Essentials.
Elsevier, Edinburg. pp 405.
Ortega-Morales A.I., Nava-Reyna E., Ávila-Rodríguez V., González-Álvarez V. H., Castillo-Martínez A., Siller-Rodríguez Q. K., Cabezas-Cruz A., Dantas-Torres
F. y Almazán C. (2019). Detection of Rickettsia spp. in Rhipicephalus sanguineus (sensu lato) collected from free-roaming dogs in Coahuila state, northern Mexico. Parasites & Vectors, 12 (130): 1-7.
Paul, W.E. (2013). Fundamental Immunology. Lippincott Williams & Wilkins, 7a ed.
Philadelphia. pp. 1603.
Paveto, C., M.C. Güida, M.I. Esteva, V. Martino, J. Coussio, M.M. Flawiá, y H.N. Torres. (2004). Anti-Trypanosoma cruzi activity of green tea (Camellia sinensis) catechins. Antimicrobial Agents and Chemotherapy, 48(1): 69-74.
Peng, Z., y F.E.R. Simons. (2004). Mosquito Allergy: Immune Mechanisms and Recombinant Salivary Allergens. International Archives of Allergy and Immunology, 133(2): 198-209.
Peng, Z., W. Xu, H. Lam, L. Cheng, A.A. James, y F.E.R. Simons. (2006). A new recombinant mosquito salivary allergen, rAed a 2: allergenicity, clinical relevance, and cross-reactivity. Allergy, 61(4): 485-490.
Peniche-Lara G., Jimenez-Delgadillo B., Munoz-Zanzi C., Cárdenas-Marrufo M., Pérez-Osorio C. y Arias-León J. (2018). Presence of Rickettsia Species in a Marginalized Area of Yucatan, Mexico. Journal of Tropical Medicine, 2018: 7675828.
Pereira, C.A., G.D. Alonso, S. Ivaudi, L.A. Bouvier, H.N. Torres, y M.M. Flawia. (2003). Screening of Substrate Analogs as Potential Enzyme Inhibitors for the Arginine Kinase of Trypanosoma cruzi. The Journal of Eukaryotic Microbiology, 50(2): 132-134.
Perner, J., J. Provazník, J. Schrenková, V. Urbanová, J.M.C. Ribeiro, y P. Kopáček. (2016). RNA-seq analyses of the midgut from blood- and serum-fed Ixodes ricinus ticks. Scientific Reports, 6: 36695.
Pieracci E. G., De la Rosa J. D. P., Rubio D. L., Solis-Perales M. E., Contreras M. V., Drexler N. A., Nicholson W. L., De la Rosa J. J. P., Chung I. H., Kato C., Behravesh C. B. y Gay-Enríquez M. A. (2019). Seroprevalence of spotted fever group rickettsiae in canines along the United States-Mexico border. Zoonoses Public Health, 66: 918-926.
Prado-Ávila S. R., Rascón-Cruz Q., Beristain-Ruiz D. M y Adame-Gallegos J. R. (2018). Identificación del agente etiológico de la anaplasmosis granulocítica humana en la garrapata café de perro en Chihuahua, México. Salud Pública de México, 60(4): 377-378.
Reyes-Clímaco L., Romero-Núñez C. y Heredia-Cardenas R. (2020). Evaluation of
Vector-Borne Diseases in Dogs in a Sub-Cold Climate Area of Mexico. Acta Biológica Colombiana, 25(2): 219-221.
Ribeiro, J.M.C., M.B. Labruna, B.J. Mans, S.R. Maruyama, I.M.B. Francischetti, G.C. Barizon, y I.K.F. de Miranda Santos. (2012). The sialotranscriptome of Antricola delacruzi female ticks is compatible with non-hematophagous behavior and an alternative source of food. Insect Biochemistry and Molecular Biology, 5: 332- 342.
Sabadin, G.A., L.F. Parizi, I. Kiio, M.A. Xavier, R. da Silva Matos, M.I. Camargo- Mathias, N.W. Ombe Githaka, V. Nene, y I. da Silva Vaz. (2017). Effect of recombinant glutathione S-transferase as vaccine antigen against Rhipicephalus appendiculatus and Rhipicephalus sanguineus infestation. Vaccine, 48: 6649-6656.
Salomon J., Fernández-Santos N. A., Zecca I. B., Estrada-Franco J. G., Davila E., Hamer G. L., Rodríguez-Pérez M.A. y Hamer S. A. (2022). Brown Dog Tick (Rhipicephalus sanguineus sensu lato) Infection with Endosymbiont and Human Pathogenic Rickettsia spp. Northern Mexico. International Journal of Environmental Research and Public Health, 19(10): 6249.
Sánchez-Montes S., Salceda-Sánchez B., Bermúdez S. E., Aguilar-Tipacamú G., Ballados-González G. G., Huerta H., Aguilar-Domínguez M., Delgado-de la Mora J., Licona-Enriquez J. D., Deldado-de la Mora D., López-Pérez A. M., Torres-Castro M.A., Alcántara-Rodrpiguez V., Becker y Colunga-Salas P., (2021). Rhipicephalus sanguineus Complex in the Americas: Systematic, Genetic Diversity, and Geographic Insights. Pathogens, 10(9): 1118
Shen, Y., M. Cao, Q. Cai, W. Su, H. Yu, W. Ruan, y G. Liu. (2011). Purification, cloning, expression and immunological analysis of Scylla serrata arginine kinase, the crab allergen. Journal of the Science of Food and Agriculture, 91(7): 1326-1335.
Shen, H., M. Cao, Q. Cai, M. Ruan, H. Mao, W. Su, y G. Liu. (2012). Purification, Cloning, and Immunological Characterization of Arginine Kinase, a Novel Allergen of Octopus fangsiao. Journal of Agricultural and Food Chemistry, 60(9): 2190-2199.
Simonis, D., y M. Chin. (2015). Physiological Characterization of Arginine Kinase Found in Caenorhabditis elegans. The FASEB Journal, 29(S1): 720-725.
Singh, S.K., y H.J. Girschick. (2003). Tick – host interactions and their immunological implications in tick-borne diseases. Current Science, 85(9): 1284-1298.
Sonenshine, D.E., y R. Roe. (2014). Biology of Ticks, 2nd ed. Oxford University Press, New York. pp 540.
Sookrung, N., W. Chaicumpa, A. Tungtrongchitr, P. Vichyanond, C. Bunnag, P. Ramasoota, P. Tongtawe, Y. Sakolvaree, y P. Tapchaisri. (2006). Periplaneta americana Arginine Kinase as a Major Cockroach Allergen among Thai Patients with Major Cockroach Allergies. Environmental Health Perspectives, 114(6): 875-880.
Szabó, M.P.J., A.J. Mangold, C.F. Joao, G. Bechera, y A.A. Guglielmone. (2005). Biological and DNA evidence of two dissimilar populations of the Rhipicephalus sanguineus tick group (Acari: Ixodidae) in South America. Veterinary Parasitology, 3: 131-140.
Thompson, R.C.A. (2013). Parasite zoonoses and wildlife: One health, spillover and human activity. Interational Journal for Parasitology, 43(12-13): 1079-1088.
Ulloa-García A., Dzul-Rosado K., Bermúdez-Castillero S. E., López-López N y Torres-Monzón J. A. (2020). Detección de Rickettsia typhi en Rhipicephalus sanguineus s.l. y Amblyomma mixtum en el sur de México. Salud Pública de México, 62: 358-363
Untalan, P.M., F.D. Guerrero, L.R. Haines, y T.W. Pearson. (2005). Proteome analysis of abundantly expressed proteins from unfed larvae of the cattle tick, Boophilus microplus. Insect Biochemistry and Molecular Biology, 35(2): 141- 151.
Valenzuela, J.G. (2004). Exploring tick saliva: from biochemistry to «sialomes» and functional genomics. Parasitology, 129: S83-S94.
Varghese, A., O. K. Raina, D. Chandra, B. R. Mirdha, N. H. Kelawala, J. B. Solanki,
N. Kumar, R. Ravindran, A. Arun, A. Rialch, H. Lalrinkima, R. N. Kelawala, y S. Samanta. (2017). Sero-detection of Toxocara canis infection in human with T. canis recombinant arginine kinase, cathepsin L-1 and TES-26 antigens. Acta Parasitologica, 62(4): 775-778
Vera, E.A. V, M. Sayé, C. Reigada, F.S. Damasceno, A.M. Silber, M.R. Miranda, y
C.A. Pereira. (2016). Resveratrol inhibits Trypanosoma cruzi arginine kinase
and exerts a trypanocidal activity. International Journal of Biological Macromolecules, 87: 498-503.
Verhoeckx, K.C.M., S. Van Broekhoven, C.F. Den Hartog-jager, M. Gaspari, G.A.H. De Jong, H.J. Wichers, E. Van Hoffen, G.F. Houben, y A.C. Knulst. (2014). House dust mite (Der p 10) and crustacean allergic patients may react to food containing Yellow mealworm proteins. Food and Chemical Toxicology, 65: 364- 373.
Wickramasinghe, S., L. Yatawara, y M. Nagataki. (2008). Development of a highly sensitive IgG-ELISA based on recombinant arginine kinase of Toxocara canis for serodiagnosis of visceral larva migrans in the murine model. Parasitology Research, 103(4): 853-858.
Yoder, J.A., J.B. Benoit, E.J. Rellinger, y J.L. Tank. (2006). Developmental profiles in tick water balance with a focus on the new Rocky Mountain spotted fever vector, Rhipicephalus sanguineus. Medical and Veterinary Entomology, 20(4): 365-372.
Yong, K., C. Hong, y T. Yong. (2007). Domestic Arthropods and Their Allergens.
Protein and Peptide Letters, 14(10): 934-942.
