Síntesis y Aplicaciones Biomédicas de Compósitos en Estado Hidrogel Empleando como Relleno Estructuras Organometálicas (MOFs)
Palabras clave:
Compositos, hidrogel, MOFs, aplicaciones biomédicasResumen
Los hidrogeles poseen una estructura tridimensional de cadenas poliméricas compuestas de grupos terminales hidrofílicos capaces de retener una gran cantidad de agua, lo que los hace mecánicamente inestables. Una manera de mejorar sus propiedades mecánicas es el uso de rellenos inorgánicos, dentro de este tipo de rellenos se tiene a las estructuras organometálicas (MOFs) que son polímeros de coordinación compuestos de iones metálicos y ligandos orgánicos, con una alta estabilidad térmica, gran área superficial y propiedades bactericidas debido a la presencia de iones metálicos. Estas características pueden combinarse con las de los hidrogeles al sintetizar sus compósitos para modular propiedades como resistencia mecánica, capacidad antimicrobiana, velocidad de degradación, capacidad de adsorción de fármacos y la modulación del metabolismo celular presente en la curación de tejido; atributos indispensables para sus aplicaciones biomédicas. Por lo que en esta revisión bibliográfica se discutirán ampliamente las propiedades de los MOFs, la síntesis y aplicaciones biomédicas de sus compósitos en estado hidrogel.
Referencias
Akhtar, M. F., Hanif, M., & Ranjha, N. M. 2016. Methods of synthesis of hydrogels: A review. Saudi Pharmaceutical Journal. 24(5): 554–559.
Ananthoji, R., Eubank, J. F., Nouar, F., Mouttaki, H., Eddaoudi, M., & Harmon, J. P. 2011. Symbiosis of zeolite-like metal-organic frameworks (rho-ZMOF) and hydrogels: Composites for controlled drug release. Journal of Materials Chemistry. 21(26): 9587–9594.
Banerjee, S., Lollar, C. T., Xiao, Z., Fang, Y., & Zhou, H. C. 2020. Biomedical Integration of Metal–Organic Frameworks. Trends in Chemistry. 2(5): 467–479.
Barbosa, J. S., Figueira, F., Braga, S. S., & Almeida Paz, F. A. (2020). Metal-organic frameworks for biomedical applications: The case of functional ligands. In M. Mouzafari (Ed), Metal-Organic Frameworks for Biomedical Applications (pp. 69–92). [En linea]. Disponible en: https://doi.org/10.1016/b978-0-12-816984-1.00005-6
Batool, S. R., Nazeer, M. A., Ekinci, D., Sahin, A., & Kizilel, S. 2020. Multifunctional alginate-based hydrogel with reversible crosslinking for controlled therapeutics delivery. International Journal of Biological Macromolecules, 150: 315–325.
Bhardwaj, N., Pandey, S. K., Mehta, J., Bhardwaj, S. K., Kim, K. H., & Deep, A. 2018. Bioactive nano-metal-organic frameworks as antimicrobials against Gram-positive and Gram-negative bacteria. Toxicology Research, 7(5): 931–941.
Bonakdar, S., Emami, S. H., Shokrgozar, M. A., Farhadi, A., Ahmadi, S. A. H., & Amanzadeh, A. 2010. Preparation and characterization of polyvinyl alcohol hydrogels crosslinked by biodegradable polyurethane for tissue engineering of cartilage. Materials Science and Engineering C, 30(4): 636–643.
Bourke, S. L., Al-Khalili, M., Briggs, T., Michniak, B. B., Kohn, J., & Poole-Warren,
L. A. 2003. A photo-crosslinked poly(vinyl alcohol) hydrogel growth factor release vehicle for wound healing applications. AAPS PharmSci, 5(4): 1–11.
Chen, J., Sheng, D., Ying, T., Zhao, H., Zhang, J., Li, Y., Xu, H., & Chen, S. 2021. MOFs-Based Nitric Oxide Therapy for Tendon Regeneration. Nano-Micro Letters, 13(1): 1–17.
Chen, W. H., Liao, W. C., Sohn, Y. S., Fadeev, M., Cecconello, A., Nechushtai, R., & Willner, I. 2018. Stimuli-Responsive Nucleic Acid-Based Polyacrylamide Hydrogel- Coated Metal–Organic Framework Nanoparticles for Controlled Drug Release. Advanced Functional Materials, 28(8): 1–9.
Claudio-Rizo, J. A., Cano Salazar, L. F., Flores-Guia, T. E., & Cabrera-Munguia, D.
A. 2020a. Estructuras metal-orgánicas (MOFs) nanoestructuradas para la liberación controlada de fármacos. Mundo Nano. Revista Interdisciplinaria En Nanociencias y Nanotecnología, 14(26): 1e-29e.
Claudio-Rizo, J. A., González-Lara, I. A., Flores-Guía, T. E., Cano-Salazar, L. F., Cabrera-Munguía, D. A., & Becerra-Rodríguez, J. J. 2020b. Study of the polyacrylate interpenetration in a collagen-polyurethane matrix to prepare novel hydrogels for biomedical applications. International Journal of Biological Macromolecules, 156: 27–39.
Claudio-Rizo, J. A., Mendoza-Novelo, B., Delgado, J., Castellano, L. E., & Mata- Mata, J. L. 2016a. A new method for the preparation of biomedical hydrogels comprised of extracellular matrix and oligourethanes. Biomedical Materials (Bristol), 11(3):035016.
Claudio-Rizo, J. A., Rangel-Argote, M., Muñoz-González, P. U., Castellano, L. E., Delgado, J., Gonzalez-García, G., Mata-Mata, J. L., & Mendoza-Novelo, B. 2016b. Improved properties of composite collagen hydrogels: Protected oligourethanes and silica particles as modulators. Journal of Materials Chemistry B, 4(40): 6497–6509.
Coradin, T., Giraud-Guille, M.-M., Helary, C., Livage, J., & Sanchez, C. 2002. A Novel Route to Collagen-Silica Biohybrids. MRS Proceedings, 726(200): Q5.2.
Ding, C., Tian, M., Feng, R., Dang, Y., & Zhang, M. 2020. Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound- Healing, and Hemostatic Properties Based on Collagen and Chitosan. ACS Biomaterials Science and Engineering, 6(7): 3855–3867.
Ege, D., Kamali, A. R., & Boccaccini, A. R. 2017. Graphene Oxide/Polymer-Based Biomaterials. Advanced Engineering Materials, 19(12): 1700627.
Feng, M., Zhang, P., Zhou, H. C., & Sharma, V. K. 2018. Water-stable metal-organic frameworks for aqueous removal of heavy metals and radionuclides: A review. Chemosphere, 209: 783–800.
Gao, N., Huang, J., Wang, L., Feng, J., Huang, P., & Wu, F. 2018. Ratiometric fluorescence detection of phosphate in human serum with a metal-organic frameworks-based nanocomposite and its immobilized agarose hydrogels. Applied Surface Science, 459: 686–692.
Gwon, K., Han, I., Lee, S., Kim, Y., & Lee, D. N. 2020. A novel metal-organic frameworks based photo-crosslinked hydrogel system for efficient antibacterial applications. ACS Applied Materials & Interfaces, 12(18):20234-20242.
Han, D., Li, Y., Liu, X., Li, B., Han, Y., Zheng, Y., Yeung, K. W. K., Li, C., Cui, Z.,
Liang, Y., Li, Z., Zhu, S., Wang, X., & Wu, S. 2020. Rapid Bacteria Trapping and Killing of Metal-Organic Frameworks Strengthened Photo-Responsive Hydrogel for Rapid Tissue Repair of Bacterial Infected Wounds. Chemical Engineering Journal, 396:125194.
Han, J., Zhou, Z., Yin, R., Yang, D., & Nie, J. 2010. Alginate-chitosan/hydroxyapatite polyelectrolyte complex porous scaffolds: Preparation and characterization. International Journal of Biological Macromolecules, 46(2): 199–205.
Horcajada, P., Chalati, T., Serre, C., Gillet, B., Sebrie, C., Baati, T., Eubank, J. F., Heurtaux, D., Clayette, P., Kreuz, C., Chang, J. S., Hwang, Y. K., Marsaud, V., Bories, P. N., Cynober, L., Gil, S., Férey, G., Couvreur, P., & Gref, R. 2010. Porous metal-organic-framework nanoscale carriers as a potential platform for drug deliveryand imaging. Nature Materials, 9(2): 172–178.
Howarth, A. J., Liu, Y., Li, P., Li, Z., Wang, T. C., Hupp, J. T., & Farha, O. K. 2016. Chemical, thermal and mechanical stabilities of metal-organic frameworks. Nature Reviews Materials, 1(15018): 1–15.
Hu, W., Wang, Z., Xiao, Y., Zhang, S., & Wang, J. 2019. Advances in crosslinking strategies of biomedical hydrogels. Biomaterials Science. 7(3): 843–855.
Huang, Y., Onyeri, S., Siewe, M., Moshfeghian, A., & Madihally, S. V. 2005. In vitro characterization of chitosan-gelatin scaffolds for tissue engineering. Biomaterials, 26(36):7616–7627.
Javanbakht, S., Hemmati, A., Namazi, H., & Heydari, A. 2020. Carboxymethylcellulose-coated 5-fluorouracil@MOF-5 nano-hybrid as a bio- nanocomposite carrier for the anticancer oral delivery. International Journal of Biological Macromolecules, 155: 876–882.
Karimi Alavijeh, R., Beheshti, S., Akhbari, K., & Morsali, A. 2018. Investigation of reasons for metal–organic framework’s antibacterial activities. Polyhedron, 156: 257–278.
Kopeček, J. 2007. Hydrogel biomaterials: A smart future? Biomaterials, 28(34): 5185–5192.
Lee, Y. J., Chang, Y. J., Lee, D. J., & Hsu, J. P. 2018. Water stable metal-organic framework as adsorbent from aqueous solution: A mini-review. Journal of the Taiwan Institute of Chemical Engineers, 93: 176–183.
Lemire, J. A., Harrison, J. J., & Turner, R. J. 2013. Antimicrobial activity of metals: Mechanisms, molecular targets and applications. Nature Reviews Microbiology, 11(6): 371–384.
Li, J., Wang, H., Yuan, X., Zhang, J., & Chew, J. W. 2020. Metal-organic framework membranes for wastewater treatment and water regeneration. Coordination Chemistry Reviews, 404: 213116.
Lian, X., & Yan, B. 2019. Diagnosis of penicillin allergy: a MOFs-based composite hydrogel for detecting β-lactamase in serum. Chemical Communications, 55(2): 241–244.
Liu, H., Peng, H., Xin, Y., & Zhang, J. 2019. Metal-organic frameworks: A universal strategy towards super-elastic hydrogels. Polymer Chemistry, 10(18): 2263–2272.
Maitra, J., & Shukla, V. K. 2014. Cross-linking in Hydrogels - A Review. American Journal of Polymer Science, 4(2): 25–31.
Mazloom-Jalali, A., Shariatinia, Z., Tamai, I. A., Pakzad, S. R., & Malakootikhah, J. 2020. Fabrication of chitosan–polyethylene glycol nanocomposite films containing ZIF-8 nanoparticles for application as wound dressing materials. International Journal of Biological Macromolecules, 153: 421–432.
McKinlay, A. C., Morris, R. E., Horcajada, P., Férey, G., Gref, R., Couvreur, P., & Serre, C. 2010. BioMOFs: Metal-organic frameworks for biological and medical applications. Angewandte Chemie - International Edition, 49(36): 6260–6266.
Motealleh, A., & Kehr, N. S. 2017. Nanocomposite Hydrogels and Their Applications in Tissue Engineering. Advanced Healthcare Materials, 6(1):1600938.
Nayak, A. K., & Das, B. (2018). Introduction to polymeric gels. In K. Pal, I. Barnejee (Eds) Polymeric Gels. Elsevier. [En linea]. Disponible en: https://doi.org/10.1016/b978-0-08-102179-8.00001-6
Opt Veld, R. C., Walboomers, X. F., Jansen, J. A., & Wagener, F. A. D. T. G. 2020. Design Considerations for Hydrogel Wound Dressings: Strategic and Molecular Advances. Tissue Engineering - Part B: Reviews, 26(3): 230–248.
Pandey, A., Dhas, N., Deshmukh, P., Caro, C., Patil, P., Luisa García-Martín, M., Padya, B., Nikam, A., Mehta, T., & Mutalik, S. 2020. Heterogeneous surface architectured metal-organic frameworks for cancer therapy, imaging, and biosensing: A state-of-the-art review. Coordination Chemistry Reviews, 409: 213212.
Peter, M., Binulal, N. S., Nair, S. V., Selvamurugan, N., Tamura, H., & Jayakumar,
R. 2010a. Novel biodegradable chitosan-gelatin/nano-bioactive glass ceramic composite scaffolds for alveolar bone tissue engineering. Chemical Engineering Journal, 158(2): 353–361.
Peter, M., Ganesh, N., Selvamurugan, N., Nair, S. V., Furuike, T., Tamura, H., & Jayakumar, R. 2010b. Preparation and characterization of chitosan- gelatin/nanohydroxyapatite composite scaffolds for tissue engineering applications. Carbohydrate Polymers, 80(3): 687–694.
Ramirez, A., & Astudillo, L. R. De. 2016. Materiales polimeros de tipo hidrogeles : revisión sobre su caracterización mediante ftir , dsc , meb , met polymers materials type hydrogels : review of their characterization by FTIR , DSC , MEB , MET. Revista Latinoamericana de Metalurgia y Materiales, 36(2): 108–130.
Rodríguez-Rodríguez, R., Espinosa-Andrews, H., Velasquillo-Martínez, C., & García-Carvajal, Z. Y. 2020. Composite hydrogels based on gelatin, chitosan and polyvinyl alcohol to biomedical applications: a review. International Journal of Polymeric Materials and Polymeric Biomaterials, 69(1): 1–20.
Rossos, A. K., Banti, C. N., Kalampounias, A., Papachristodoulou, C., Kordatos, K., Zoumpoulakis, P., Mavromoustakos, T., Kourkoumelis, N., & Hadjikakou, S. K. 2020. pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens. Materials Science and Engineering C, 111: 110770.
Safaei, M., Foroughi, M. M., Ebrahimpoor, N., Jahani, S., Omidi, A., & Khatami, M. 2019. A review on metal-organic frameworks: Synthesis and applications. TrAC - Trends in Analytical Chemistry, 118: 401–425.
Sarkar, C., Chowdhuri, A. R., Garai, S., Chakraborty, J., & Sahu, S. K. 2019. Three- dimensional cellulose-hydroxyapatite nanocomposite enriched with dexamethasone loaded metal–organic framework: a local drug delivery system for bone tissue engineering. Cellulose, 26(12): 7253–7269.
Sheffield, C., Meyers, K., Johnson, E., & Rajachar, R. 2018. Application of Composite Hydrogels to Control Physical Properties in Tissue Engineering and Regenerative Medicine. Gels, 4(2): 51.
Singh, A., Sharma, P. K., Garg, V. K., & Garg, G. 2010. Hydrogels: A review. International Journal of Pharmaceutical Sciences Review and Research, 4(2): 97– 105.
Tabata, Y. 2009. Biomaterial technology for tissue engineering applications. Journal of the Royal Society Interface, 6:S311-S324.
Tan, G., Zhong, Y., Yang, L., Jiang, Y., Liu, J., & Ren, F. 2020. A multifunctional MOF-based nanohybrid as injectable implant platform for drug synergistic oral cancer therapy. Chemical Engineering Journal, 390: 124446.
Thakur, S., Sharma, B., Verma, A., Chaudhary, J., Tamulevicius, S., & Thakur, V. K. 2018. Recent progress in sodium alginate based sustainable hydrogels for environmental applications. Journal of Cleaner Production, 198: 143–159.
Tsou, T. L., Tang, S. T., Huang, Y. C., Wu, J. R., Young, J. J., & Wang, H. J. 2005.
Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies. Journal of Materials Science: Materials in Medicine, 16(2): 95– 100.
Tylingo, R., Gorczyca, G., Mania, S., Szweda, P., & Milewski, S. 2016. Preparation and characterization of porous scaffolds from chitosan-collagen-gelatin composite. Reactive and Functional Polymers, 103: 131–140.
Vedadghavami, A., Minooei, F., Mohammadi, M. H., Khetani, S., Rezaei Kolahchi, A., Mashayekhan, S., & Sanati-Nezhad, A. 2017. Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications. Acta Biomaterialia, 62: 42–63.
Wahid, F., Zhong, C., Wang, H. S., Hu, X. H., & Chu, L. Q. 2017. Recent advances in antimicrobial hydrogels containing metal ions and metals/metal oxide nanoparticles. Polymers, 9(12): 636.
Wang, L., Xu, H., Gao, J., Yao, J., & Zhang, Q. 2019. Recent progress in metal- organic frameworks-based hydrogels and aerogels and their applications. Coordination Chemistry Reviews, 398: 213016.
Wu, J., & Sailor, M. J. 2009. Chitosan hydrogel-capped porous SiO2 as a pH responsive nano-valve for triggered release of insulin. Advanced Functional Materials, 19(5): 733–741.
Wyszogrodzka, G., Marszałek, B., Gil, B., & Dorozyński, P. 2016. Metal-organic frameworks: Mechanisms of antibacterial action and potential applications. Drug Discovery Today, 21(6): 1009–1018.
Xiao, J., Chen, S., Yi, J., Zhang, H. F., & Ameer, G. A. 2017. A Cooperative Copper Metal–Organic Framework-Hydrogel System Improves Wound Healing in Diabetes. Advanced Functional Materials, 27(1): 1–10.
Yao, X., Zhu, G., Zhu, P., Ma, J., Chen, W., Liu, Z., & Kong, T. 2020. Omniphobic ZIF-8@Hydrogel Membrane by Microfluidic-Emulsion-Templating Method for Wound Healing. Advanced Functional Materials, 30(13): 1–9.
Yu, X., Zhao, T., Qi, Y., Luo, J., Fang, J., Yang, X., Liu, X., Xu, T., Yang, Q., Gou, Z., & Dai, X. 2018. In vitro Chondrocyte Responses in Mg-doped Wollastonite/Hydrogel Composite Scaffolds for Osteochondral Interface Regeneration. Scientific Reports, 8(1): 1–9.
Yu, Y., Chen, G., Guo, J., Liu, Y., Ren, J., Kong, T., & Zhao, Y. 2018. Vitamin metal- organic framework-laden microfibers from microfluidics for wound healing. Materials Horizons, 5(6): 1137–1142.
Zhang, C., Hong, S., Liu, M., Yu, W., Zhang, M., & Zhang, L. 2020. pH-sensitive MOF integrated with glucose oxidase for glucose-responsive insulin delivery. Journal of Controlled Release, 320: 159–167.
Zhang, Shu, Pei, X., Gao, H., Chen, S., & Wang, J. 2019. Metal-organic framework- based nanomaterials for biomedical applications. Chinese Chemical Letters. 31(5): 1060-1070.
Zhang, Siqi, Ye, J., Sun, Y., Kang, J., Liu, J., Wang, Y., Li, Y., Zhang, L., & Ning, G. 2020. Electrospun fibrous mat based on silver (I) metal-organic frameworks- polylactic acid for bacterial killing and antibiotic-free wound dressing. Chemical Engineering Journal, 390: 124523.
Zhu, J. 2010. Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials, 31(17): 4639–4656.
