Evaluación de residuos vegetales de la industria de alimentos como fuente de carbohidratos fucosilados
Palabras clave:
aprovechamiento de residuos, compuestos bioactivos, fucosa, hemicelulosa, xiloglucanoResumen
La fucosa es un monosacárido presente en diversas macromoléculas: carbohidratos, glicolípidos y glicoproteínas; desempeña un papel crucial en diversos eventos de interacción celular y forma parte de la estructura de oligosacáridos de leche humana, importantes para la salud de los lactantes. Para la síntesis de estos es deseable contar con sustratos donadores de fucosa que no liberen subpro-ductos tóxicos. Los xiloglucanos fucosilados emergen como una pro-metedora fuente de fucosa. Estos son polisacáridos química y estruc-turalmente diversos que forman parte de la pared celular primaria de muchas plantas terrestres, haciendo una red con las microfi-brillas de celulosa. En muchos cultivos vegetales para consumo humano se han encontrado xiloglucanos fucosilados, por lo que la biomasa procedente de los residuos vegetales de la industria de ali-mentos es una fuente aprovechable de obtención de estos carbohidratos. Además, ya hay evidencia de obtención, por vía enzimática, de oligosacáridos de leche humana a partir de xiloglucano de manzana y lactosa, lo cual corrobora la utilidad de este polisacárido. El aprovechamiento de desechos agroindustriales para obtener fuco-sa a través del xiloglucano fucosilado abre nuevas perspectivas para la producción de compuestos bioactivos benéficos para la salud.
Referencias
Abdelkader Attia, M.A. (2018). Enzymology of the xyloglucan utilization system in the soil saprophyte cell Vibrio japonicus [Tesis de doctorado, The University of British Columbia]. http://hdl.handle.net/2429/64723
Alonso-Simón, A., Neumetzler, L., García-Angulo, P., Encina, A.E., Acebes, J.L., Álvarez, J.M. & Hayashi, T. (2010). Plasticity of xyloglucan composition in bean, (Phaseolus vulgaris)-cultured cells during habituation and dehabituation to lethal concentrations of dichlobenil. Molecular Plant. 3:603–609. DOI: 10.1093/mp/ssq011
Beltrán-Ramírez, F., Orona-Tamayo, D., Cornejo-Corona, I., González-Cervantes, J.L.N., Esparza-Claudio, J.J. & Quintana-Rodríguez, E. (2019). Agro-industrial waste revalorization: The growing biorefinery. In: Abomohra, A. (Ed.), Biomass for Bioenergy - Recent Trends and Future Challenges, ItechOpen. Australia, pp. 1-20.
Biel-Nielsen, T.L. (2021). New process for production of high-value cell wall derived products from citrus peel [Tesis de doctorado, Denmark Technical University]. https://findit.dtu.dk/en/catalog/62a75f15cf4b841a6a3a3cc5
Biel-Nielsen, T.L., Li, K., Sørensen, S.O., Sejberg, J.J.P., Meyer, A.S. & Holck, J. (2022). Utilization of industrial citrus pectin side streams for enzymatic production of human milk oligosaccharides. Carbohydrate Research. 519:108627. DOI: 10.1016/j.carres.2022.108627
Brennan, M., Fakharuzi, D. & Harris, P.J. (2019). Occurrence of fucosylated and non-fucosylated xyloglucans in the cell walls of monocotyledons: An immunofluorescence study. Plant Physiology and Biochemistry. 139:428-434. DOI: 10.1016/j.plaphy.2019.04.005
Cantu-Jungles, T.M., Cipriani, T.R., Iacomini, M., Hamaker, B.R. & Cordeiro, L. M. (2017). A pectic polysaccharide from peach palm fruits (Bactris gasipaes) and its fermentation profile by the human gut microbiota in vitro. Bioactive Carbohydrates and Dietary Fibre. 9:1-6. DOI: 10.1016/j.bcdf.201 6.11.005
Cascales, E.V., Prencipe, D., Nocentini, C., Sánchez, R.L. & García, J.M.R. (2021). Characteristics and composition of hackberries (Celtis australis L.) from mediterranean forests. Emirates Journal of Food Agriculture. 33:37-44. DOI: 10.9755/ejfa.2021.v33.i1.2375
Dehors, J., Mareck, A., Kiefer-Meyer, M.C., Menu-Bouaouiche, L., Lehner, A. & Mollet, J.C. (2019). Evolution of cell wall polymers in tip-growing land plant gametophytes: composition, distribution, functional aspects and their remodeling. Frontiers in Plant Science. 10:441. DOI: 10.3389/fpls.2019.00441
Düsterhöft, E.M., Posthumus, M.A. & Voragen, A.G.J.J. (1992). Non-starch polysaccharides from sunflower (Helianthus annuus) meal and palm-kernel (Elaeis guineensis) meal—investigation of the structure of major polysaccharides. Journal of the Science of Food and Agriculture. 59(2):151–160. DOI: 10.1002/jsfa.2740590204
Dutta, P., Giri, S. & Kumar, G. (2020). Xyloglucan as green renewable biopolymer used in drug delivery and tissue engineering. International Journal of Biological Macro-molecules. 160:55-68. DOI: 10.1016/j.ijbiomac.2020. 05.148
Garber, J.M., Hennet, T. & Szymanski, C.M. (2021). Significance of fucose in intestinal health and disease. Molecular Micro-biology. 115(6):1086-1093. DOI: 10.1111/mmi.14681
González-Sánchez, M.E., Pérez-Fabiel, S., Wong-Villarreal, A., Bello-Mendoza, R. & Yañez-Ocampo, G. (2015). Residuos agro-industriales con potencial para la producción de metano mediante la digestión anaerobia. Revista Argentina de Micro-biología. 47:229-235. DOI: 10.1016/j.ram.201 5.05.003
Günl, M., Neumetzler, L., Kraemer, F., de Souza, A., Schultink, A., Pena, M., York, W.S. & Pauly, M. (2011). AXY8 encodes an L-fucosidase, underscoring the importance of apoplastic metabolism on the fine structure of Arabidopsis cell wall polysaccharides. The Plant Cell. 23:4025-4040. DOI: 10.1105/tpc.111.089193
Hayashi, T., Kato, Y. & Matsuda, K. (1980). Xyloglucan from suspension-cultured soybean cells. Plant Cell Physiology. 21:1405–1418. DOI: 10.109 3/pcp/21.8.1405
Hilz, H., Bakx, E.J., Schols, H.A. & Voragen, A.G.J. (2005). Cell wall polysaccharides in black currants and bilberries—characterisation in berries, juice, and press cake. Carbo-hydrate Polymers. 59:477–488. DOI: 10.1016/j.carbpol.2 004.11.002
Hotchkiss, A.T., Chau, H.K., Strahan, G.D., Nuñez, A., Simon, S., White, A.K., Dieng, S., Heuberger, E.R., Yadav, M.P. & Hirsch, J. (2021). Structure and composition of blueberry fiber pectin and xyloglucan that bind anthocyanins during fruit puree processing. Food Hydrocolloids. 116:106572.
Hsiung, SY., Li, J., Imre, B., Kao, M.R., Liao, H.C., Wang, D., Chen, C.H., Liang, P.H., Harris, P.J. & Hsieh, Y.S.Y. (2013). Struc-tures of the xyloglucans in the monocotyledon family Araceae (aroids). Planta. 257:39. DOI: 10.1007/s00425-023-04071-w
Kato, Y., Noro, O. & Azuma, Y. (2000). Analysis of the oligosaccharides of xyloglucan in peanut hulls. (Studies on production of fucose-containing xyloglucan oligosaccharide Part II). Journal of the Japanese Society for Food Science and Technology. 47(7):560-563. DOI: 10.3136/ns kkk.47.560
Kosmala, M., Milala, J., Kołodziejczyk, K., Markowski, J., Mieszczakowska, M., Ginies, C. & Renard, C.M.G.C. (2009). Characterization of cell wall polysaccharides of cherry (Prunus cerasus var. Schattenmorelle) fruit and pomace. Plant Foods Human Nutrition. 64:279–285. DOI: 10.1007 /s11130-009-0134-z
Lezyk, M., Jers, C., Kjaerulff, L., Gotfredsen, C.H., Mikkelsen, M.D. & Mikkelsen, J.D. (2016). Novel α-L-fucosidases from a soil metagenome for production of fucosylated human milk oligosaccharides. PLOS ONE. 11(1):e014 7438. DOI: 10.1371/ journal.pone.0147438
Li, K., (2022). Discovery and characterization of fungal xyloglucanases for citrus peel valorization [Tesis de doctorado, Denmark Technical University]. https://findit.dtu.dk/en/c atalog/63f61ff5 29d79f917fcf9136
Lin, Z., Pattathil, S., Hahn, M.G. & Wicker, L. (2019). Blueberry cell wall fractionation, characterization and glycome profiling. Food Hydrocolloids. 90:385–393. DOI: 10.1016/j.foodhyd.2018.12.051
Louis, P., Solvang, M., Duncan, S., Walker, A. & Mukhopadhya, I. (2021). Dietary fibre complexity and its influence on function-nnal groups of the human gut microbiota. Proceedings of the Nutrition. Society. 80:386-397. doi:10.1017/S0029665121 003694
Madrazo de la Garza, J.A. (2017). Oligosacáridos de la leche humana: crecimiento y desarrollo. Acta Pediátrica Mexicana. 5:295-298. DOI: 10.18233/apm38no5pp295-2981468
McDougall, G.J. & Fry, S.C. (1989). Structure-activity relationships for xyloglucan oligosaccharides with antiauxin activity. Plant Physiology. 89:883–887. DOI: 10.1104/pp.89.3.883
Meng, J., Zhu, Y., Wang, N., Zhang, W. & Mu, W. (2023). Recent advances in a functional deoxy hexose L-fucose: Occurrence, physiological effects, and preparation. Trends in Food Science and Technology. 138:16-26. DOI: 10.1016/j.tifs.2023.05 .011
Miedes Vicente, E. (2007). Caracterización funcional de la enzima de la pared celular xiloglucano, endotransglucosidasa [Tesis de doctorado, Universitat de Valencia]. https://dialnet.unirio ja.es/servlet/tesis?codigo=76142
Mikkelsen, M.D., Harholt, J., Westereng, B., Domozych, D., Fry, S.C., Johansen, I.E., Fangel, J.U., Łężyk, M., Feng, T., Nancke, L., Mikkelsen, J.D., Willats, W. G.T. & Ulvskov, P. (2021). Ancient origin of fucosylated xyloglucan in charophycean green algae. Communications Biology. 4:754. DOI: 10.1038/s42003-021-02277-w
Minjares, F.R., Feminia, A., Garau, M.C., Candelas, M.G., Simal, S. & Rosselló, C. (2016). Ultrasound-assisted extraction of hemicelluloses from grape pomace using response surface methodology. Carbohydrate Polymers. 138:180-191. DOI: 10.1016/j.carbpol.2015.11.045
Moya-Gonzálvez, E.M., Peña-Gil, N., Rubio-del-Campo, A., Coll-Marqués, J.M., Gozalbo-Rovira. R., Monedero, V., Rodríguez-Díaz, J. & Yebra, M.J. (2022). Infant gut microbial metagenome mining of α-L-fucosidases with activity on fucosylated human milk oligosaccharides and glycolcon-jugates. Microbiology Spectrum. 10:e0177522. DOI: 10.11 28/spectrum.01775-22
Park, J.Y., Shin, M.S., Kim, S.N., Kim, H.Y., Kim, K.H., Shin, K.S. & Kang, K.S. (2016). Polysaccharides from korean citrus hallabong peels inhibit angiogenesis and breast cancer cell migration. International Journal of Biological. Macromole-cules. 85:522-529. DOI: 10.1016/j.ijbiomac.2016.01.015.
Park, Y.B. & Cosgrove, D.J. (2015). Xyloglucan and its interactions with other components of the growing cell wall. Plant Cell Physiology. 56:180–194. DOI: 10.1093/pcp/pcu204
Pauly, M. & Keegstra, K. (2016). Biosynthesis of the plant cell wall matrix polysaccharide xyloglucan. Annual Review of Plant Biology. 67:235–259. DOI: 10.1146/annurevarplant-0430 15-112222.
Putri, N.I., Celus, M., Van Audenhove, J., Nanseera, R.P., Van Loey, A. & Hendrickx, M. (2022). Functionalization of pectin-depleted residue from different citrus by-products by high pressure homogenization. Food Hydrocolloids. 129:107638. DOI: 10.1016/j.foodhyd.2022.107638
Rosa, F., Sharma, A.K., Gurung, M., Casero, D., Matazel K., Bode, L., Simecka, C., Elolimy, A.A., Tripp, P., Randolph, C., Hand, T.W., Williams, K.D., LeRoith, T. & Yeruva, L. (2022). Human milk oligosaccharides impact cellular and inflammatory gene expression and immune response. Frontiers in Immunology. 13. DOI: 10.3389/fimmu.2022.907529
Sabater, C. (2015). Síntesis e identificación de oligosacáridos derivados de lactosa y lactulosa a partir de permeado de suero de quesería. Tesis de Maestría. Universidad Autónoma de Madrid, España.
Satari, B. & Karimi, K. (2018). Citrus processing wastes: environmental impacts, recent advances, and future perspec-tives in total valorization. Resources, Conservation and Recy-cling. 29:53-167. DOI: 10.1016/j.resconrec .2017.10. 032
Schultink, A., Liu, L., Zhu, L. & Pauly, M. (2014). Structural diversity and function of xyloglucan sidechain substituents. Plants (Basel). 3:526–542. DOI: 10.3390/plants3040526
Shi, R., Yang, S., Wang, N., Yan, Q.J., Yan, X.M. & Jiang, Z.Q. (2022). Synthesis of 2′-fucosyllactose from apple pomace–derived xyloglucan oligosa-ccharides by an α-L-fucosidase from Pedobacter sp. CAU209. Applied Microbiology and Biotechnology. 107:3579–3591. DOI: 10.1007/s002 53-023-12533-0
Smiderle, F.R., Ruthes, A.C., van Arkel, J., Chanput, W., Iacomini, M., Wichers, H. J. & Van Griensven L.J.L.D. (2011). Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show similarities in their structures and their immunomodulatory effects on human monocytic THP-1 cells. BMC Complementary and Alternative Medicine. 11:58. DOI: 10.1186/1472-6882-11-58
Thomès, L. & Bojar, D. (2021). The role of fucose-containing glycan motifs across taxonomic kingdoms. Frontiers in Molecular Biosciences. 8. DOI: 10.3389/fmolb.2021.755577
Vieira, P.S., Bonfim, I.M., Araujo, E.A., Melo, R.R., Lima, A.R., Fessel, M.R., Paixão, D.A.A., Persinoti, G.F., Rocco, S.A., Lima, T.B., Pirolla, R.A.S., Morais, M.A.B., Correa, J.B.L., Zanphorlin, L.M., Diogo, J.A., Lima, E.A., Grandis, A., Buckeridge, M.S., Gozzo, F.C., Benedetti, C.E., Polikarpov, I., Giuseppe, P.O. & Murakami, M.T. (2021). Xyloglucan processing machinery in Xanthomonas pathogens and its role in the transcriptional activation of virulence factors. Nature Communica-tions. 12:4049. DOI: 10.1038/s41467-021-24277-4
Zavyalov, A.V., Rykova, S.V., Luninab, N.A., Sushkovaa, V.I., Yarotskya, S.V. & Berezinaa, O.V. (2019). Plant polysaccharide xyloglucan and enzymes that hydrolyze it (Review). Russian Journal of Bioorganic Chemistry. 45:845-859. DOI: 10.1134/S1068162019070148
Zeuner, B., Muschiol, J., Holck, J., Lezyk, M., Gedde, M.R., Jers, C., Mikkelsen, J.D. & Meyer, A.S. (2018). Substrate specificity and transfucosylation activity of GH29 α-L-fucosidases for enzymatic production of human milk oligosaccharides. New Biotechnology. 41:34-45. DOI: 10.1016/j.nbt. 2017.12.002
Zeuner, B., Vuillemin, M, Holck, J., Muschiol, J. & Meyer, A.S. (2020). Improved transglycosylation by a xyloglucan-active α-L-fucosidase from Fusarium graminearum. Journal of Fungi (Basel). 6:295. DOI: 10.3390/jof6040295