Relationship Between High Dietary Protein Intake and Kidney Damage: A Systematic Review

Abstract

A high dietary protein intake has been identified as a risk factor for the progression of established chronic kidney disease. However, over the years, research has focused on determining whether this same high protein intake in individuals without pre-existing renal disease could lead to progressive kidney damage and, consequently, be a triggering factor for kidney disease over time. To address this question, this meta-analysis evaluates a series of 14 selected studies from a total of 97, based on eligibility criteria related to hyperproteinemia and renal damage. Through data analysis, our study concludes that there is no evidence supporting or refuting the role of dietary protein intake on renal function in the absence of chronic kidney disease.