Disfunción inmunometabólica en el VIH: bases epistemológicas

Abstract

The relationship between metabolic syndrome

and proinflammatory cytokines in people living with HIV has

not been conclusively established. It is suggested that chronic

inflammation, derived from viremia and metabolic

alterations, could explain this association. This article

proposes an epistemological reflection aimed at

strengthening scientific understanding and the application of

bioethics in future epidemiological research. Materials and

methods: A qualitative study was conducted with a

hermeneutic and epistemological approach. A documentary

and critical analysis of scientific articles, systematic reviews,

and regulatory documents related to HIV, cytokines, and

metabolic syndrome was performed. Results: The analysis

allowed us to identify patterns and ethical and

epistemological implications in the reviewed literature. The

ideas of David Hume on experience-based knowledge and

Bradford Hill on the criteria of causality in epidemiology are

taken up as references for the construction of scientific

knowledge. In conclusion, the integration of philosophical

and bioethical thought into medical research allows us to

reinterpret knowledge from a humanistic perspective,

recovering lessons from the past to guide science toward a

more reflective, ethical, and socially responsible practice