Acute Liver Injury Associated with DILI Due to Itraconazole: Case Report

Abstract

This is the case of a 24-year-old woman with a history of vaginal candidiasis, treated with itraconazole 3 times a day for one month. She presented with abdominal pain, acholia, choluria, profuse gingival bleeding, and jaundice. Drug-induced liver injury (DILI) is defined as a common and severe adverse drug reaction, characterized by liver damage caused by a medication or herbal product, leading to abnormal liver function tests or hepatic dysfunction, after excluding other potential causes. Medications, herbs, and dietary supplements can induce several types of liver damage depending on the severity of the injury. Most of these reactions are either asymptomatic or cause mild symptoms that resolve after discontinuation of the offending drug. DILI is typically detected through elevated liver enzymes, with or without signs of liver disease. It can lead to acute liver failure or chronic liver disease. This case emphasizes the importance of early recognition of potential cases of liver injury associated with prolonged drug.