Combination of Cannabidiol and Current Medicinal Drugs

Abstract

This work aimed to review the literature on the combination de Cannabidiol and current medicinal drugs. A search in PubMed and Google Scholar was performed. We use the following keywords combination: CBD plus, analgesic, anticonvulsants, antibiotics, antipsychotics, antidepressants, antineoplastics, antiemetics, and anesthetics. Original articles with in vitro, in vivo assays, and clinical trials were selected. Current literature reports mainly in vitro and in vivo studies where CBD is evaluated in combination with other medicinal drugs for epilepsy, pain, depression, infections, and psychosis with promising results. There are few studies on the combination of CBD plus medicinal drugs, however, they suggest that CBD seems to act synergically with the studied drugs, and more confirmatory studies are needed. CBD is a potent CYP3A4 and CYP2C19 Inhibitor; therefore, potential interactions should be considered.